Society of University SurgeonsCongenital diaphragmatic hernia in the preterm infant
Section snippets
Data
The Congenital Diaphragmatic Hernia Study Group (CDHSG) was formed in 1995 to compile data on live-born neonates with CDH to allow assessment of therapies and outcome. Data are collected on all inborn or transferred infants with CDH to form the Congenital Diaphragmatic Hernia Registry (CDHR). The CDHSG is a voluntary collaboration of international tertiary referral centers providing care for CDH patients who provide data to a central registry (participating centers specified in the appendix).
Results
In all, 5,069 live-born infants with CDH were identified from the CDHR. GA data were available in 5,022 patients. Also included were 3,895 term infants (77.6%) and 1,127 preterm infants (22.4%). Most defects were left-sided (81.5%) with 1% bilateral lesions. Preterm infants had a higher percentage of chromosomal anomalies (8.1% vs 4.0%; P < .0001) and major cardiac defects (11.8% vs 6.1%; P < .0001). Descriptive statistics for all variables are shown in Table I.
Discussion
Despite advances in neonatal critical care, prematurity remains a significant contributor to neonatal mortality in infants with CDH. The incidence of prematurity has increased in the last decade and remains a major cause of mortality in all neonates.12 Although the severity of pulmonary hypoplasia and hypertension are the major determinants of overall survival for infants with CDH, some mortality may be attributed to prematurity because of an increase in associated anomalies. Ninety-five
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The authors are part of the writing committee for the Congenital Diaphragmatic Hernia Study Group. The members of the Congenital Diaphragmatic Hernia Study Group are listed in the appendix.