Once-daily tiotropium Respimat® 5 μg is an efficacious 24-h bronchodilator in adults with symptomatic asthma
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Keywords
Asthma
Tiotropium
Dosing regimen
Bronchodilator efficacy
Anticholinergic drug
Long-acting bronchodilator
Abbreviations
ACQ-7
seven-question Asthma Control Questionnaire
AM2+®
Asthma Monitor2+ device
AUC
area under the curve
AUC(0–τ),ss
area under the curve over a uniform dosing interval τ at steady state
AUC(0–24h),ss
area under the curve over 24 h at steady state
BID
twice-daily
CI
confidence interval
Cmax,ss
steady-state maximum plasma concentration
CV
coefficient of variation
fe(0–24h),ss
urinary excretion over 24 h at steady state (expressed as percentage of dose)
FEV1
forced expiratory volume in 1 s
FEV1 AUC(0–24h)
forced expiratory volume in 1 s area under the curve from 0 to 24 h
FVC
forced vital capacity
ICS
inhaled corticosteroids
LABA
long-acting β2-agonist
peak FEV1(0–24h)
peak forced expiratory volume in 1 s measured within 24 h of the last evening inhalation
PEF
peak expiratory flow
PEFam
morning peak expiratory flow
PEFpm
evening peak expiratory flow
QD
once-daily
SD
standard deviation
SE
standard error
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Present address: Inamed GmbH, Robert-Koch-Allee 29, 82131 Gauting, Germany.
Copyright © 2015 The Authors. Published by Elsevier Ltd.