Original articleA prospective comparative evaluation of persistent respiratory morbidity in esophageal atresia and congenital diaphragmatic hernia survivors☆
Section snippets
Methods
This longitudinal, observational, prospective, cohort study consists of repeated measurements at 6, 12, and 24 months and at 5 years.
Results
Baseline characteristics for both groups of children are shown in Table 1. All CDH patients were born after a gestational age of at least 36 weeks; 4 EA patients were born before 36 weeks of gestation at 28, 29, 31, and 33 weeks, respectively. All but one EA children underwent primary anastomosis via a lateral thoracotomy within 48 hours. One patient had a type A long gap atresia and underwent delayed primary anastomosis after 3 months. Bronchoscopic evaluation of tracheomalacia during the
Discussion
We prospectively evaluated respiratory morbidity and factors interrelating with pulmonary disease during the first 5 years in 2 groups of children born with major congenital anatomical malformations of the respiratory tract—EA and CDH. Both groups showed recurrent respiratory tract infections, abnormally low FEV1 in 25% of patients, no increase of FEno levels, and decreased maximal exercise tolerance. In addition, a high incidence of GER and impaired physical growth were observed in both groups.
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Monique H. van der Cammen-van Zijp received an unrestricted grant from Fonds Nuts-Ohra, grant number 0701-83.