Original articleBreast-Feeding Duration and Infant Atopic Manifestations, by Maternal Allergic Status, in the First 2 Years of Life (KOALA Study)
Section snippets
Study Population
The study subjects were mother–infant pairs previously enrolled in the KOALA Birth Cohort Study between 2000 and 2002.5 We recruited participants with diverse lifestyles (“conventional” and “alternative”) who were at 34 weeks of gestation. The women with a conventional lifestyle (n = 2343) were recruited from an ongoing prospective cohort study on pregnancy-related pelvic girdle pain in The Netherlands. The women with an alternative lifestyle (n = 491) were recruited through various channels,
Results
Of the 2834 infants enrolled at birth, 3 were excluded because of Down syndrome and 126 because of missing information on breast-feeding, leaving 2705 infants for the study. The response rate for the questionnaire at age 2 years was 93% (n = 2516). Home visits at age 2 years were made in 818 infants. Most infants were breast-fed (85%; n = 2287). Mothers in the alternative recruitment group had a higher rate and a longer duration of breast-feeding compared with those in the conventional
Discussion
We found that longer duration of breast-feeding was associated with a decreased risk for recurrent wheeze in the first 2 years of life, regardless of the mother’s allergy history. Moreover, longer duration of breast-feeding was associated with a decreased risk of eczema (by questionnaire) in infants of mothers without allergy or asthma. When atopic dermatitis (according to UK-WP criteria), increased total IgE levels, or sensitization were taken as the outcome, no associations with
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Supported by The Netherlands Organisation for Health Research and Development (Zon-Mw), program of Innovative Prevention Research (Prevention Program 1, no. 210-00-090).
The sponsoring organization had no involvement in the study design, data collection, analysis, or interpretation, or in writing of the report or the decision to submit the manuscript for publication. There are no conflicts of interest to report.