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Maternal obesity during pregnancy as a risk for early-life asthma

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Cited by (46)

  • Maternal obesity and childhood wheezing and asthma

    2017, Paediatric Respiratory Reviews
    Citation Excerpt :

    Several other studies evaluated the associations between maternal obesity and asthma in older children [33–37]. In a registry-based study of 189,783 children born in Stockholm, Sweden higher maternal BMI was consistently associated with an increased risk of asthma in the child [33]. Asthma was assessed in terms of asthma medication use and hospitalization at different ages during the first ten years of life.

  • Persistent influence of maternal obesity on offspring health: Mechanisms from animal models and clinical studies

    2016, Molecular and Cellular Endocrinology
    Citation Excerpt :

    In the Generation R study, maternal obesity was associated with an increased risk of childhood overweight and a clustering of cardiometabolic risk factors at 6 years of age (Whitaker et al., 1997; Gaillard et al., 2014). Maternal obesity correlates with higher offspring blood pressure in children (Godfrey et al., 1994; Margetts et al., 1991; Moraeus et al., 2012) and teenagers (Laor et al., 1997), increased risk of asthma and wheezing in children (Lowe et al., 2011) and adolescents (Patel et al., 2012), as well as decreased cognitive performance (of modest effect size) in children ages 5–7 (Basatemur et al., 2013) and increased risk of affective problems such as depression in children from ages 5–17 (Robinson et al., 2013). Maternal obesity is also associated with an increase in adipogenic potential in umbilical cord mesenchymal stem cells, demonstrating that programming effects of maternal obesity are present at birth and persistent in fetal tissues even after removal from the maternal obesity mileu (Jones et al., 2009).

  • Drosophila melanogaster: An emerging model of transgenerational effects of maternal obesity

    2016, Molecular and Cellular Endocrinology
    Citation Excerpt :

    The offspring of obese females are at increased risk for fetal macrosomia, shoulder dystocia, and increased birth weight (Leddy et al., 2008). There is also evidence suggesting maternal overnutrition increases the offspring's risk of developing type 2 diabetes, obesity, cardiovascular disease, and asthma in later childhood (Catalano et al., 2009a,b; Clausen et al., 2009; Diesel et al., 2015; Forno et al., 2014; Lowe et al., 2011; Nohr et al., 2009). For the mother, maternal obesity also correlates with an increase in cardiovascular disease and premature death later in life (Lee et al., 2015).

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Supported by the Swedish Research Council, through the Umeå SIMSAM node, Umeå University (http://www.phmed.umu.se/english/divisions/epidemiology/research/the-umea-simsam-node/), provided financial support to A.L. and L.B. to undertake this project. Also, A.L. was supported by the Australian National Health and Medical Research Council while this study was developed.

Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.

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