Asthma and lower airway diseaseMaternal interpersonal trauma and cord blood IgE levels in an inner-city cohort: A life-course perspective
Section snippets
Participants
Participants were from the Asthma Coalition on Community, Environment, and Social Stress project, a prospective cohort originally funded to recruit 500 pregnant women and their children to study the effects of prenatal maternal and early-life stress on urban childhood asthma risk, as described elsewhere.17 Briefly, English- or Spanish-speaking pregnant women who were at least 18 years old and receiving prenatal care at Brigham & Women's Hospital, Boston Medical Center, 3 metropolitan Boston
Results
Table I, Table II describe sample characteristics stratified by periods of IPT over the mother's life course and by IgE categories, respectively. Overall maternal age was 26.6 ± 5.7 years. The sample was largely Hispanic (59%) or black (30%, Table I). More respondents experienced no IPT than early (60% vs 22%, P < .001), late (60% vs 6%, P < .001), or chronic (60% vs 12%, P < 0.001) IPT. More Hispanics relative to blacks or other/mixed race subjects reported no IPT (66% vs 52% [P < .003] and
Discussion
These analyses provide the first suggestion that chronic exposure to IPT across the mother's life course is associated with increased IgE levels in newborns when adjusted for race/ethnicity, childhood and current SES, other current NLEs, household allergens, season of birth, and potential mediators (eg, prenatal smoking, birth weight for gestational age, maternal atopy and IgE level). Although results are most consistent with cumulative life-course effects in the mother potentiating the child's
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The Asthma Coalition on Community, Environment, and Social Stress study was funded by grants R01ES10932, U01HL072494, and R01HL080674. M. S. is supported by grant T32-ES07069-29 and the Leaves of Grass Foundation.
Disclosure of potential conflict of interest: M. J. Sternthal and R. J. Wright have received research support from the National Institutes of Health and the Leaves of Grass Foundation. M. B. Enlow has received research support from the National Institute of Mental Health and the Children's Brain Research Foundation. S. Cohen has received research support from the National Institutes of Health and the MacArthur Foundation and consulted for Johnson & Johnson Consumer and Personal Products Worldwide. The rest of the authors have declared that they have no conflict of interest.