Asthma and lower airway diseaseAngiopoietin-2 as a contributing factor of exercise-induced bronchoconstriction in asthmatic patients receiving inhaled corticosteroid therapy
Section snippets
Subjects
Nonsmoking subjects with clinically stable asthma aged 20 to 40 years, receiving inhaled beclomethasone dipropionate (BDP; 800 μg/d) for more than 6 months, and having the ability to complete an exercise challenge test were recruited to participate in this study. Exclusion criteria included current smokers or exsmokers with more than a 5 pack-year history, clinically significant medical disorders except asthma, concurrent use of certain respiratory medications (long-acting β2-agonists,
Results
Thirty-two asthmatic patients and 14 age-matched healthy control subjects were included in this study (Table I). Because all asthmatic patients were receiving inhaled BDP therapy for more than 6 months, they were clinically stable and complained of neither wheezing nor dyspnea at rest. Although the results of baseline pulmonary function were significantly lower in asthmatic patients than in healthy control subjects, all asthmatic patients exhibited relatively normal FEV1 and FEV1/forced vital
Discussion
In this study we selected clinically stable asthmatic patients who were already receiving inhaled corticosteroid therapy for more than 6 months. Exhaled NO concentrations, percentages of eosinophils, and ECP levels in induced sputum did not differ significantly between asthmatic patients and healthy control subjects, indicating that airway inflammation in asthmatic patients and healthy control subjects were at similar levels. Moreover, we observed that many of our asthmatic patients had
References (35)
- et al.
Vascular involvement in exercise-induced airway narrowing in patients with bronchial asthma
Chest
(2002) - et al.
Airway immunopathology of asthma with exercise-induced bronchoconstriction
J Allergy Clin Immunol
(2005) - et al.
Role of endogenous nitric oxide in exercise-induced airway narrowing in patients with bronchial asthma
J Allergy Clin Immunol
(2000) - et al.
Increased levels of nitric oxide derivatives in induced sputum in patients with asthma
J Allergy Clin Immunol
(1997) - et al.
Effect of inhaled beclomethasone dipropionate on peroxynitrite inhibitory activity in induced sputum from asthmatic patients
Chest
(2003) - et al.
Effect of ciclesonide dose and duration of therapy on exercise-induced bronchoconstriction in patients with asthma
J Allergy Clin Immunol
(2006) - et al.
Angiopoietin 2 is required for postnatal angiogenesis and lymphatic patterning, and only the later role is rescued by angiopoietin 1
Dev Cell
(2002) - et al.
Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis
Lab Invest
(2000) - et al.
Roles of angiopoietin-1 and angiopoietin-2 on airway microvascular permeability in asthmatic patients
Chest
(2007) - et al.
Montelukast versus salmeterol in patients with asthma and exercise-induced bronchoconstriction. Montelukast/Salmeterol Exercise Study Group
J Allergy Clin Immunol
(1999)
Exercise-induced bronchospasm in children: effects of asthma severity
Am J Respir Crit Care Med
Hypothesis: exercise-induced asthma as a vascular phenomenon
Lancet
Exercise-induced asthma
N Engl J Med
Asthma: from bronchoconstriction to airways inflammation and remodeling
Am J Respir Crit Care Med
Role of microvascular permeability on physiologic differences in asthma and eosinophilic bronchitis
Am J Respir Crit Care Med
Inflammatory basis of exercise-induced bronchoconstriction
Am J Respir Crit Care Med
Severity of exercise-induced bronchoconstriction is related to airway eosinophilic inflammation in patients with asthma
Eur Respir J
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Exercise-induced bronchoconstriction update—2016
2016, Journal of Allergy and Clinical ImmunologyMast cells and basophils in inflammatory and tumor angiogenesis and lymphangiogenesis
2016, European Journal of PharmacologyCitation Excerpt :Moreover, Ang1 contributes to lymphatic vessel formation through the activation of Tie2 (Thomas and Augustin, 2009). Increasing evidence suggests that Angs are involved in human inflammatory diseases including asthma (Kanazawa et al., 2008; Prevete et al., 2013), and systemic lupus erythematosus (SLE) (Kumpers et al., 2009) in addition to cancer (Huang et al., 2010). Angiogenin, produced by macrophages, ECs, and lymphocytes is one of the most potent tumor-derived angiogenic factors (Fett et al., 1985).
Approach to the Patient with Exercise-Induced Bronchoconstriction
2014, Middleton's Allergy: Principles and Practice: Eighth EditionPathogenesis, prevalence, diagnosis, and management of exercise-induced bronchoconstriction: A practice parameter
2010, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :The increase in this ratio has been shown to relate to severity of EIB. Furthermore, vascular endothelial growth factor and angiopoietin 2 also stimulate MVP, and levels of these substances measured after exercise are also related to severity of EIB.126–128 The potential role for increased MVP in the pathophysiology of EIB is clear in that it could act to amplify the airway narrowing caused by BSM contraction.
Angiogenesis and remodelling in asthma
2009, Revue Francaise d'AllergologieAirway injury as a mechanism for exercise-induced bronchoconstriction in elite athletes
2008, Journal of Allergy and Clinical ImmunologyCitation Excerpt :An increased MVP after exercise has been demonstrated by an increase in the sputum/serum ratio of albumin and is related to the severity of EIB (Fig 4).102 Many mediators increase MVP, and these include histamine, PGD2, LTC4, and Substance P.103 Vascular endothelial growth factor and angiopoietin 2 also stimulate MVP, and levels after exercise are related to the severity of EIB.104,105 Furthermore, the angiopoietin 2 levels in asthmatic subjects were reduced with montelukast, and this might contribute to their mode of action in enhancing recovery from bronchoconstriction.106
Supported by Grant-in-Aid for Scientific Research (no. 17590800) from the Japan Society for the Promotion of Science.
Disclosure of potential conflict of interest: The authors have received grant support from a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science.