Asthma diagnosis and treatmentEffects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children
Section snippets
Study subjects
Four groups of white children were studied: 20 healthy nonatopic nonasthmatic children, 20 atopic nonasthmatic children, 30 steroid-naive atopic children with stable mild intermittent asthma, and 25 atopic children with stable mild-to-moderate persistent asthma who were receiving inhaled corticosteroids (Table I). Atopic nonasthmatic children and atopic asthmatic children were recruited from the Allergy outpatient Clinic of the Istituto Dermopatico dell'Immacolata, IDI, Rome, Italy, and the
Results
No α-amylase concentrations were detected in any study sample, excluding significant salivary contamination.
Discussion
Because its capture is completely noninvasive, EBC is potentially useful for long-term monitoring of lung inflammation in children with asthma,20 but there is no information on the utility of this technique in atopic nonasthmatic children or whether atopy per se affects the measurements of exhaled eicosanoids. Previous studies reported increased concentrations of LTs and 8-isoprostane in EBC in children with asthma, but these values were not compared with those in atopic nonasthmatic children.6.
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Cited by (0)
This work was performed at the Catholic University of the Sacred Heart, Rome, Italy.
Supported by academic funds 2003-2004 from the Catholic University of the Sacred Heart, Rome, Italy.