Penicillin-bound polyacrylate nanoparticles: Restoring the activity of β-lactam antibiotics against MRSA
Graphical abstract
Polyacrylate nanoparticles bearing penicillin antibiotics attached to the polymeric matrix have been prepared in water by emulsion polymerization. The nanoparticles are uniformly 25–40 nm in diameter and are stable over a wide range of pH values and in blood serum. The nanoparticle emulsions display potent in vitro activity against Staphylococcus aureus and retain their full antibiotic capabilities against β-lactamase producing, methicillin-resistant S. aureus, suggesting their use as therapies for drug-resistant bacterial infections.
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Acknowledgments
We thank Dr. Thomas Koob (Shriners Hospital, Tampa) for assistance with performing the cytotoxicity experiments, Gil Brubaker (University of Florida Particle Engineering Research Center) for helping with particle analyses, and August Heim (University of South Florida) for assistance with AFM imaging experiments. Financial support from the National Institutes of Health (R01 AI051351) and National Science Foundation (0620572) is gratefully acknowledged. We sincerely thank the NSF-IGERT (DGE
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