Traffic density as a surrogate measure of environmental exposures in studies of air pollution health effects: Long-term mortality in a cohort of US veterans
Section snippets
Introduction and background
The past decade has seen substantial growth in the publication of studies of the health effects of ambient air pollution. All of the regulated pollutants have been implicated in these various studies, and in many cases it has been difficult to distinguish their separate contributions (Stieb et al., 2002). Moreover, urban air pollution is a complex mixture of thousands of compounds, of which there has been limited characterization. One way to simplify this problem is to analyze health effects in
Measures and indicators of vehicular emissions
The general classifications of vehicular emissions include combustion products, fuel additives and impurities, detritus from wear and degradation of specific components (including road surfaces), and noise. Some of these are unique to vehicles but, in general, noise and gaseous combustion products are not. Their respective chemical and physical properties vary greatly, as do their rates of human physiological uptake and retention and the types of health impacts that may be involved. In
Comparison of density variables
VKTA is highly correlated with population and housing densities and thus could be considered a measure of congestion in general. Data on population and housing densities are available by zip (postal) code for the Veterans Cohort and thus are better measures of any true density effect, which can be obscured by local density variations within a county, as discussed above. As shown in Table 3A, the RRs of county-level traffic density consistently exceed those of population or housing densities at
Discussion
The low risk estimates for CO in this study have been seen in other long-term studies and may be due in part to the localized nature of this pollutant, which can lead to exposure errors when data from centralized monitors are used to represent an entire county. It is also likely that the health effects of CO are non-linear and exhibit a threshold. The RRs indicated for LVKTA are generally higher than those seen for traffic-related air pollutants in short-term time-series studies, in contrast to
Conclusions
Traffic sources have been implicated in recent air pollution epidemiology studies, but uncertainties remain as to the specific agents and thus causal mechanisms that might be involved (in part because of uncertainties in estimated exposures). In ecological studies from previous decades, increased mortality was associated with population density, which could also implicate traffic density. Since then, traffic levels have about doubled, but pollutant emissions per vehicle and average ambient
Acknowledgments
Funding for this study was provided by the Electric Power Research Institute (EPRI). Portions of the research described in this paper were funded by the US Department of Energy through the National Energy Technology Laboratory. We thank Dr. S.C. Morris for help with the zip-code density data and two anonymous reviewers for helpful comments.
References (47)
- et al.
The health effects of air pollution: a reanalysis
Journal of Urban Economics
(1982) - et al.
Rural and urban traffic fatalities, vehicle miles, and population density
Accident Analysis and Prevention
(2004) - et al.
Ambient nitrogen dioxide and distance from a major highway
Science of the Total Environment
(2003) - et al.
Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study
Lancet
(2002) Air pollution and mortality: specification searches using SMSA-based data
Journal of Environmental Economics and Management
(1984)- et al.
The response of lung epithelium to well characterized fine particles
Life Sciences
(1998) - et al.
On the logarithmic distance between NO2 concentration and the distance from a highroad
Science of the Total Environment
(2004) - et al.
Study of ultrafine particles near a major highway with heavy-duty diesel traffic
Atmospheric Environment
(2002) - Bull, A., (compiler) 2004. Traffic Congestion: The Problem and How to Deal With It. United Nations Publications,...
Extending SAS Survival Analysis Techniques for Medical Research
(1997)
Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators
Environmental Health Perspectives
Traffic air pollution and mortality rate advancement periods
American Journal of Epidemiology
How do the indoor size distributions of airborne submicron and ultrafine particles in the absence of significant indoor sources depend on outdoor distributions?
Indoor Air
PM10 and asthma medication in schoolchildren
Archives of Environmental Health
Traffic density in California: socioeconomic and ethnic differences among potentially exposed children
Journal of Exposure Analysis and Environmental Epidemiology
Inner city air pollution and respiratory health and atopy in children
European Respiratory Journal
Estimation of long-term average exposure to outdoor air pollution for a cohort study on mortality
Journal of Exposure Analysis and Environmental Epidemiology
Health effects caused by noise: evidence in the literature from the past 25 years
Noise and Health
Triggering risk factors for ischemic stroke
Neurology
Air Pollution and Human Health
Climate, traffic-related air pollutants and allergic rhinitis prevalence in middle-school children in Taiwan
European Respiratory Journal
A Statistical Study of the Macroepidemiology of Air Pollution and Total Mortality
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