Original articleGeneral thoracicEndobronchial Ultrasound-Guided Miniforceps Biopsy in the Biopsy of Subcarinal Masses in Patients with Low Likelihood of Non-Small Cell Lung Cancer
Section snippets
Material and Methods
From January 2006 to January 2007, consecutive patients referred for bronchoscopy and with subcarinal masses greater than 25 mm in the short axis on chest computed tomography were enrolled prospectively in the study. Patients with known or suspected non-small cell lung cancer undergoing mediastinal staging for this disease were not included because we and others have previously shown that EBUS-guided TBNA has excellent diagnostic yield in this population [7]. The study was approved by the
Results
These sequential techniques were performed at bronchoscopy in 74 patients (41 men) with a median age of 53 years (range, 27 to 71 years). The specimens obtained were suitable for analysis in all cases. A final diagnosis was available for all patients at follow-up and allowed calculation of the diagnostic yield for each technique of lymph node sampling (Table 1). The mean size of the masses sampled was 3.27 cm (range, 2.5 to 4.2 cm), and no significant correlation was seen between the size of
Comment
Chest physicians are commonly involved in the assessment of patients with mediastinal lymphadenopathy. In the past these patients were commonly referred directly for a surgical biopsy through a mediastinoscopy. The advent of endoscopic and EBUS guidance in the last few years, which increase the yield from TBNA [5, 6, 7], as well as a recognition that in practice mediastinoscopy may not be used as well as it could [11], interest has been growing in noninvasive sampling of mediastinal lymph
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