MiscellaneousComparison of Cardiac Structural and Functional Changes in Obese Otherwise Healthy Adults With Versus Without Obstructive Sleep Apnea
Section snippets
Methods
We recruited community-dwelling healthy adult men with obesity (body mass index ≥30 kg/m2). We studied 23 otherwise healthy newly diagnosed patients with moderate to severe OSA (apnea-hypopnea index ≥15 events/hour) and 18 healthy obese subjects proved to be free of OSA on complete overnight polysomnography (apnea-hypopnea index <5 events/hour). Exclusion criteria were a history of myocardial ischemia or electrocardiographic changes suggestive of ischemia, a history of hypertension or systemic
Results
A total of 23 otherwise healthy patients with moderate to severe OSA and 18 healthy obese subjects without OSA were included in the study. All patients with OSA were diagnosed by overnight polysomnography as having moderate to severe OSA by an apnea-hypopnea index ≥15 events/hour for the exposure group and <5 events/hour for the controls. Baseline characteristics of the patients are listed in Table 1. The 2 groups had similar mean ages, body mass indexes, heart rates, and systolic and diastolic
Discussion
The novel and important findings of the present study are, first, that patients with newly diagnosed moderate to severe OSA have impaired LV diastolic function by tissue Doppler velocity and have increased left atrial size. Second, LV mass, although increased in OSA, is similar to that seen in obese controls without OSA. Patients with OSA also tended toward impaired RV diastolic function, as evidenced by attenuation in tissue Doppler lateral tricuspid annular diastolic velocity and superior
Acknowledgment
We thank Eileen McMahon, PhD, and Carolyn Duenwald, BS, for excellent technical support.
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- 1
Drs. Otto, Svatikova, and Somers are supported by Grants HL-65176, HL-61560, HL-70602, HL-73211-01, and M01-RR00585 from the National Institutes of Health, Bethesda, Maryland.
- 2
Dr. Belohlavek is supported by Grant HL-68555 from the National Institutes of Health and Grant #0245016N from the American Heart Association, Dallas, Texas.
- 3
Dr. Otto was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior and Fundação E. J. Zerbini (InCor), São Paulo, Brazil.