Elsevier

Microbes and Infection

Volume 4, Issue 9, July 2002, Pages 903-914
Microbes and Infection

Forum in Immunology
Toll receptors, CD14, and macrophage activation and deactivation by LPS

https://doi.org/10.1016/S1286-4579(02)01613-1Get rights and content
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Abstract

This review will focus on the molecular mechanisms of macrophage activation and desensitization by bacterial lipopolysaccharide (LPS). The most recent advances in the understanding of the function of the LPS receptor complex and its role in the development of the septic shock syndrome and endotoxin tolerance will be discussed.

Keywords

Toll-like receptors (TLR)
CD14
Lipopolysaccharide (LPS)
Signal transduction
Macrophage
Endotoxin tolerance
Septic shock
Inflammation
Cytokines

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1

New address: Department of Microbiology and Immunology, University of Maryland, Baltimore, 655 W. Baltimore Street 13-009, Baltimore, MD 21205, USA