ORIGINAL ARTICLESThe Current Dilemma with Spirometric Inclusion Criteria for Asthma Drug Trials
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2005, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Patients in such trials generally must meet precisely defined criteria regarding symptom scores, spirometry, and freedom from possibly confounding conditions, medications, and smoking. Consequently, most asthma investigators find that only a small percentage of patients with asthma are appropriate evaluable subjects for asthma trials.12 In trials designed to show equivalence, the incentive to conduct trials with such rigor would be reduced, making recruitment for the trial easier, but potentially compromising the validity of the trial.
The evaluable subject
1998, Annals of Allergy, Asthma and ImmunologyEnvironmental Causes of Asthma
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