Literature reviewRisk factors for bronchiolitis obliterans: a systematic review of recent publications
Section snippets
Methods
We performed a manual search on Medline to identify studies published since January 1990. In addition, we examined reviews and reference lists from published studies. No attempt was made to extract unpublished data. All studies that included the terms “obliterative bronchiolitis” or “bronchiolitis obliterans syndrome” and the term “lung Transpl∗” were considered and abstracts were read. Further investigation was confined to studies on risk factors so that the following were excluded: non-human
Studies
The initial search identified 588 publications. Exclusion of non-human studies; those published before 1990; and studies solely concerned with mechanism, diagnosis, or treatment of OB left 75 articles that were copied and read in full. References of these articles are available from the authors (LDS). From these papers, 50 were either superceded by later articles, were not related to risk factors, or contained insufficient information on any risk factors to be included in the review. The
Discussion
This review reveals the current evidence for risk factors for BOS and OB in the published literature. Since the adoption of the internationally accepted physiologic definition of BOS,3 almost all studies have focused on risk factors for this surrogate measure of OB. Earlier studies concentrated on histologically defined OB, but such studies were small and less robust. Thus, it is not possible to reliably differentiate between risk factors for BOS and those for OB from published work.
The
References (28)
- et al.
Post-transplant obliterative bronchiolitis and other late lung sequelae in human heart-lung transplantation
Chest
(1984) - et al.
Transforming growth factor beta (TGF-β) and obliterative bronchiolitis following pulmonary transplantation
Journal Heart Lung Transplant
(1999) - et al.
Bronchiolitis obliterans in recipients of single, double and heart-lung transplantation
Chest
(1995) - et al.
ATG induction therapy and the incidence of bronchiolitis obliterans after lung transplantationdoes it make a difference?
Transplant Proc
(1998) - et al.
Risk factors for the development of bronchiolitis obliterans syndrome after lung transplantation
J Thorac Cardiovasc Surg
(1997) - et al.
Surveillance transbronchial lung biopsiesimplication for survival after lung transplantation
J Thorac and Cardiovasc Surg
(2000) - et al.
Does human leukocyte antigen matching influence the outcome of lung transplantation? An analysis of 3,459 lung transplantations
J Heart Lung Transplant
(2000) - et al.
Effect of development of antibodies to HLA and cytomegalovirus mismatch on lung transplantation survival and development of bronchiolitis obliterans syndrome
J Thorac Cardiovasc Surg
(1998) - et al.
Impact of graft ischaemic time on outcomes after bilateral sequential single-lung transplantation
Ann Thorac Surg
(1999) - et al.
The registry of the International Society for Heart and Lung Transplantationseventeenth official report—2000
J Heart Lung Transplant
(2000)