Novel IKK inhibitors: β-carbolines
β-Carboline 1 was identified as a nonselective IκB kinase inhibitor. Optimization of this β-carboline natural product derivative resulted in a novel class of selective IKK inhibitors with IC50s in the nanomolar range and with biological activities in whole cells and in vivo.
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Acknowledgements
The authors are grateful to Olaf Ritzeler and Andreas Batzer of Aventis, Frankfurt for scientific discussions.
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