The host inflammatory response prior to death in patients with cystic fibrosis and chronic Pseudomonas aeruginosa infection
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Cited by (23)
Sputum neutrophils in cystic fibrosis patients display a reduced respiratory burst
2013, Journal of Cystic FibrosisCitation Excerpt :However, in patients with an FEV1 less than 40% of predicted the relationship with lung function was less clear, but these neutrophils displayed high levels of ROS production. CF patients in the final stages of lung disease have been shown to mount an unrelenting systemic inflammatory response that is difficult to manage [55]. The potential role of neutrophils in this process suggests targeted neutrophil stabilising strategies as well as anti-microbial therapy may be of benefit.
Management of respiratory diseases
2013, Tidy's Physiotherapy: Fifteenth EditionCytokines and inflammatory mediators in cystic fibrosis
2004, Journal of Cystic FibrosisIron deficiency in cystic fibrosis: Relationship to lung disease severity and chronic Pseudomonas aeruginosa infection
2002, ChestCitation Excerpt :Detectable circulating cytokines such as tumor necrosis factor-α and interleukin-8, which are released in response to bacterial infection, can reduce the systemic availability of iron by diverting it away from hemoglobin synthesis, and they also contribute to the anorexia and cachexia of chronic disease.2223 Increased levels of these circulating inflammatory mediators have been demonstrated in CF patients, and data suggest that production is up-regulated during exacerbations and during the terminal phases of the disease.2425 Additionally, tumor necrosis factor-α up-regulates cellular ferritin messenger RNA synthesis, and increased tissue iron deposition within the lung could potentially provide a reservoir of iron for PA acquisition.26