The role of dendritic cells in the induction and regulation of immunity to microbial infection

doi:10.1016/S0952-7915(99)80066-1

Current Opinion in Immunology

Volume 11, Issue 4, August 1999, Pages 392-399

https://doi.org/10.1016/S0952-7915(99)80066-1 Get rights and content

Dendritic cells (DCs) play a critical role in the initiation and regulation of immune responses. Recent advances have begun to uncover the nature and diversity of DC-pathogen interactions and the modulation of DC function by microbial stimuli. Antigen pulsed DCs have also been shown in several infection models to induce high levels of protective immunity and to display immunotherapeutic potential. The study of the function of DCs in the response to infection is thus an exciting and rapidly expanding field with important implications for both fundamental and clinical immunology.

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The role of dendritic cells in the induction and regulation of immunity to microbial infection

J Exp Med

J Immunol

J Immunol

J Exp Med

Dendritic cells and the control of immunity

Nature

Dendritic cells

Curr Opin Hematol

Virus interactions with dendritic cells

J Gen Virol

Dendritic cells and T lymphocytes: developmental and functional interactions

The evolution of self-tolerance: a new cell arises to meet the challenge of self-reactivity

Immunol Today

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

J Exp Med

Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking

Science

Re

Immunity

Inhibition of Langerhans cell antigen-presenting function by IL-10: a role for IL-10 in induction of tolerance

J Immunol

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Bur J Immunol

Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential

J Immunol

Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells

J Exp Med

CDBα+ and CD8α− subclasses of dendritic cells direct the development of distinct T helper cells in vivo

J Exp Med

Distinct dendritic cell subsets differentially regulate the class of immune response in vivo

In vivo microbial stimulation induces rapid CD40L-independent production of IL-12 by dendritic cells and their re-distribution to T cell areas

J Exp Med

Analysis of adjuvant function by direct visualization of antigen presentation in vivo: endotoxin promotes accumulation of antigen-bearing dendritic cells in the T cell areas of lymphoid tissue

J Immunol

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J Exp Med

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Nature

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