The collectins in innate immunity

https://doi.org/10.1016/S0952-7915(96)80101-4Get rights and content

Abstract

The collectins are proteins with collagen tails and globular lectin domains that appear to play an important role in mammalian first line host defense. Recent insights have clarified the structural basis of ligand recognition, the interactions of collectins with complement cascades, and the association with disease susceptibility.

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      Citation Excerpt :

      This binding promotes clearance of pathogens via neutralisation, agglutination, and/or phagocytosis (Kawai and Akira, 2010). Collectins belong to a family of evolutionarily conserved mammalian pattern recognition molecules that are characterized by calcium-dependent (C-type lectin) carbohydrate binding domain (Epstein et al., 1996). Its members include surfactant protein A and D (SP-A and SP-D), mannose-binding lectin (MBL), scavenger receptor collectin placenta-1 (CL-P1), collectin liver-1 (CL-L1), collectin kidney-1 (CL-K1), conglutinin, collectin of 43 kDa (CL-43), and collectin of 46 kDa (CL-46) (Kishore et al., 2006).

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