The collectins in innate immunity
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Equine β-defensin 1 regulates cytokine expression and phagocytosis in S. aureus-infected mouse monocyte macrophages via the Paxillin-FAK-PI3K pathway
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2016, ImmunobiologyCitation Excerpt :This binding promotes clearance of pathogens via neutralisation, agglutination, and/or phagocytosis (Kawai and Akira, 2010). Collectins belong to a family of evolutionarily conserved mammalian pattern recognition molecules that are characterized by calcium-dependent (C-type lectin) carbohydrate binding domain (Epstein et al., 1996). Its members include surfactant protein A and D (SP-A and SP-D), mannose-binding lectin (MBL), scavenger receptor collectin placenta-1 (CL-P1), collectin liver-1 (CL-L1), collectin kidney-1 (CL-K1), conglutinin, collectin of 43 kDa (CL-43), and collectin of 46 kDa (CL-46) (Kishore et al., 2006).
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