Trends in Genetics
Volume 11, Issue 12, December 1995, Pages 513-519
Journal home page for Trends in Genetics

Polygenic disease: methods for mapping complex disease traits

https://doi.org/10.1016/S0168-9525(00)89163-5Get rights and content

Abstract

Improved genotyping technology has made it feasible to use a genetic approach to map genes involved in the etiology of common human diseases. We discuss here recent developments in several different statistical approaches to linkage analysis of these traits, including affected-sib-pair methods, the affected-pedigree-member method, regressive models and linkage-disequilibrium-based approaches. We discuss advantages and disadvantages of the various approaches, as well as factors influencing study design and the ability to detect loci. Statistical methodology in this area is advancing rapidly and will help enable the mapping and cloning of loci involved in susceptibility to common multifactorial diseases.

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