CommentNanoscience, nanotoxicology, and the need to think small
References (10)
- et al.
An introduction to the short-term toxicology of respirable industrial fibres
Mutat Res
(2004) - et al.
Particulate air-pollution and acute health-effects
Lancet
(1995) - et al.
Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects
Toxicol Lett
(2004) There's plenty of room at the bottom: an invitation to enter a new field of physics
Engineering Sci
(1960)Engines of creation
(1986)
Cited by (121)
Toxic mechanisms of Roth801, Canals, microparticles and nanoparticles of ZnO on MG-63 osteoblasts
2021, Materials Science and Engineering CCitation Excerpt :The GADD45α induction is mediated by activation of NF-kB and mitogen-activated protein kinases (MAPKs) [56]. Aspiration of nanoparticles has been found to induce oxidative stress, tissue inflammation, lung fibrosis and cardiovascular diseases etc. [47,57]. On the contrary, lower concentrations (0.01 μg/ml) of ZnO nano-particles decrease ROS level of MC3T3-E1 osteoblasts and attenuate the antimycin A-induced cell damage [36].
Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives
2021, Seminars in Cancer BiologyCitation Excerpt :Summarized in Table 1 are nanotherapeutics that are in clinical trial stages. Nanomaterials, which often constitute the most important part of the nano-technological products, shows considerable variation in their biological activity as well as toxicity based on surface chemistry [193]. In contrast, nanoparticles represent a huge health hazard since they are capable of penetrating the barriers present within the body and reaching the biological systems [194].
Risk assessments in nanotoxicology: bioinformatics and computational approaches
2020, Current Opinion in ToxicologyCitation Excerpt :Nanotoxicology was defined in 2004 as a new subcategory of toxicology addressed to evaluate the risks and potential threats caused by the rapidly growing industry of nanotechnology [1]. Despite previous concerns and fears about nanotechnology [4], the main concepts of nanotoxicology were developed between 2004 and 2005 [1,5,6]. The main challenge of nanotoxicology is in variation between the physicochemical properties of NPs and bulk materials (greater than 500 nm), even if they have the same chemical composition [7].
Current challenges and coming opportunities in nanoparticle risk assessment
2020, Frontiers of Nanoscience