Elsevier

The Lancet

Volume 359, Issue 9311, 23 March 2002, Pages 1036-1037
The Lancet

Research Letters
Association between genetic variation in the gene for insulin-like growth factor-l and low birthweight

https://doi.org/10.1016/S0140-6736(02)08067-4Get rights and content

Summary

Low birthweight is associated with later risk of type 2 diabetes and related disorders. We aimed to show that a polymorphism in the gene for insulin-like growth factor-l, which has proved to raise risk of type 2 diabetes and myocardial infarction, is associated with low birthweight. We recorded birthweight and obtained DNA for 463 adults. Individuals who did not have the wild-type allele of the polymorphism had a 215 g lower birthweight than those homozygous for this allele (95% Cl −411 to −10). Our data lend support to the hypothesis that genetic variation affecting fetal growth could account for the association between low birthweight and susceptibility to diabetes and cardiovascular disease in later life.

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