Allergens as proteases: An aspergillus fumigatus proteinase directly induces human epithelial cell detachment
References (19)
- et al.
Allergic bronchopulmonary aspergillosis
Chest
(1984) - et al.
Fungal pneumonias. Part 3. Allergic bronchopulmonary aspergillosis
Chest
(1981) - et al.
Enzyme profile and immunochemical characterization of Aspergillus fumigatus antigens
J Allergy Clin Immunol
(1986) - et al.
Esterolytic, elastase-like activity of purified alkaline proteinase from Aspergillus sojae
Biochim Biophys Acta
(1971) - et al.
Protease antigens from the house dust mite
Lancet
(1989) Allergic aspergillosis: review of 32 cases
Thorax
(1968)- et al.
Correlation of elastase production by some strains of Aspergillus fumigatus with ability to cause pulmonary invasive aspergillosis in mice
Infect Immun
(1984) - et al.
Study of human epithelial cell detachment and damage: development of a model
Immunol Cell Biol
(1989) The neutral and alkaline proteases of Aspergillus nidulans
J Gen Microbiol
(1973)
Cited by (103)
Recent advances in fungal serine protease inhibitors
2022, Biomedicine and PharmacotherapyCitation Excerpt :Based on their substrate specificity, they can be categorized into three groups: trypsin-, chymotrypsin-, or elastase-like. The fungal elastase activity has emerged as the major indicator of virulence and has been associated with penetrating mice lungs [49], deterioration of respiratory function [50], and lung injury [51]. Moreover, proteinases such as elastases have important functions in the pathogenesis of dermatophytes during skin, nail, and hair colonization.
Allergic Bronchopulmonary Aspergillosis
2021, Encyclopedia of Respiratory Medicine, Second EditionMass spectrometry-based identification of allergens from Curvularia pallescens, a prevalent aerospore in India
2016, Biochimica et Biophysica Acta - Proteins and ProteomicsCitation Excerpt :Vacuolar proteases like serine proteases were already stated allergenic in several fungi such as Aspergillus sp. [42,43], Cladosporium cladosporioides [44], Cladosporium herbarum [45] and C. lunata [21], aspartyl proteases from Rhizopus oryzae [46] and so on. Fungal proteases were also known to cause allergic aspergillosis [47]. The role of proteases in eliciting allergic response has also been documented in other indoor allergy such as cat (Fel d 1) and house dust mite (Der p 1, Der p 3, Der p 6 and Der p 9) [48,49].
Actinidin, a protease from kiwifruit, induces changes in morphology and adhesion of T84 intestinal epithelial cells
2012, PhytochemistryCitation Excerpt :The endogenous protease activity of actinidin may cause rapid protein degradation after tissue disruption (Bublin et al., 2008, 2010). Inhalatory allergen proteases from house dust mites, fungi and pollen with enzymatic properties have been shown to induce changes in morphology, adhesion and permeability of the pulmonary epithelium contributing to the pathogenesis of asthma (Kauffman et al., 2006; Robinson et al., 1990; Tomee et al., 1997; Runswick et al., 2007). It is possible that proteolytically active food allergens, as actinidin, might exhibit similar activity on the intestinal epithelium, thus contributing to food allergy sensitisation.
Key strongylid nematodes of animals - Impact of next-generation transcriptomics on systems biology and biotechnology
2012, Biotechnology AdvancesCitation Excerpt :Molecules encoding peptides predicted to be associated with the nervous system (i.e., ‘transthyretin-like’ and ‘neuropeptide-like'proteins; TTLs and NLPs, respectively), digestion of host proteins or inhibition of host proteases (i.e., proteases and protease inhibitors, respectively) were highly represented in the T. colubriformis transcriptome (Cantacessi et al., 2010a), with serine- and metallo-proteases and ‘Kunitz-type’ protease inhibitors being the vast majority of molecules characterised (Cantacessi et al., 2010a). In strongylid nematodes, these molecules play fundamental roles in the invasion of the vertebrate host by mediating, for example, tissue penetration, feeding and/or immuno-evasion by (i) digesting antibodies; (ii) cleaving cell-surface receptors for cytokines and/or (iii) causing the direct lysis of immune cells (Björnberg et al., 1995; Hotez and Prichard, 1995; Robinson et al., 1990; Shaw et al., 2003; Williamson et al., 2003b). In H. contortus, 454 sequencing and bioinformatic analyses were used to explore differences in gene transcription between the free-living (L3) and the parasitic (xL3) third larval stage and to predict the roles that key transcripts play in the metabolic pathways linked to larval development (Cantacessi et al., 2010b).
First transcriptomic analysis of the economically important parasitic nematode, Trichostrongylus colubriformis, using a next-generation sequencing approach
2010, Infection, Genetics and EvolutionCitation Excerpt :Previously, serine- and metalloproteases have been identified in the excretory/secretory products (ES) from L4s and adults of T. vitrinus (MacLennan et al., 1997, 2005), and shown to be active at various pHs (MacLennan et al., 1997). It has been suggested that these proteases might facilitate the survival of the parasite in the host by mediating, for example, tissue penetration, feeding and/or immuno-evasion by (i) digesting antibodies (Hotez and Prichard, 1995); (ii) cleaving cell-surface receptors for cytokines (Björnberg et al., 1995) and/or (iii) causing the direct lysis of immune cells (Robinson et al., 1990). Proteases expressed on the epithelial surface of the gut of nematodes have been the focus of a number of studies, aimed at exploring their potential as vaccine candidates, particularly in blood-feeding nematodes (Knox et al., 2003; Williamson et al., 2003; Loukas et al., 2005a; Bethony et al., 2006; Pearson et al., 2009; Ranjit et al., 2009).
- 1
From the Department of Medicine, University of Western Australia, and Mycology Section, State Health Laboratories, Queen Elizabeth II Medical Center, Nedlands, Australia.