Asthma, Rhinitis, Other Respiratory DiseasesAssociation of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations☆
Section snippets
Methods
Asthma cases in the African American, US white, and US Hispanic populations were collected by using criteria established as part of the Collaborative Study on the Genetics of Asthma.7 Control subjects for this group had no history of asthma and no first-degree relatives with asthma. Dutch probands with clinical asthma were originally characterized between 1962 and 1975.8, 9 Between 1990 and 1998, 200 probands and their spouses, children, and available grandchildren were studied. The probands
Results
Some variability in allele frequency was observed among the 4 populations (Fig 1).2 For asthma susceptibility, significant associations were observed to at least one of the 8 SNPs within each population, but no single SNP was consistently associated with a specific asthma phenotype across all of the groups (Table I). The most significant associations were observed in the Dutch asthma population with SNPs ST+7 and V4 by using a codominant model (P = .0093 and P = .0009, respectively).
Discussion
The report of ADAM33 as a positionally cloned gene for asthma2 represents an important development in understanding susceptibility to asthma, allergy, and closely related phenotypes.12, 13 Thus, it is necessary to evaluate the importance of this observation by replicating it in different populations and further delineating the role of this gene in asthma. The purpose of this study was to evaluate variation in ADAM33 in 3 ethnic groups in the United States (African American, white, and
Acknowledgements
We thank all participants in the study and E. Gankema, H. Koops, M. Leever, D. Faber, Betsy Rechsteiner, Regina Smith, and Laurie Adams, who assisted in the clinical testing. We also thank C.I.M. Panhuysen, B. Meijer, G.G. Meijer, and Pamela Amelung for their work in patient recruitment.
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Association of ADAM33 gene polymorphisms with asthma in Mongolian and Han groups in Inner Mongolia
2018, Saudi Journal of Biological SciencesMatrix metalloproteinase (MMP)-2 -1306 C > T gene polymorphism affects circulating levels of MMP-2 in Egyptian asthmatic patients
2016, Gene ReportsCitation Excerpt :Studies containing thousands of genetic variants have been used to establish associations among asthma and control cases (Ferreira et al., 2011). Thus, gene polymorphism may play a vital role in asthma pathogenesis and improve asthma management (Howard et al., 2003). Matrix metalloproteinases (MMPs) are a large group of calcium-dependent and zinc-containing endopeptidases that cleave proteins and proteoglycan constituents of the extracellular matrix (ECM), in addition to multiple non-matrix substrates including cytokines, chemokines, growth factors and growth factor receptors (Zitka et al., 2010).
Association of ADAM33 gene S1 and S2 transmembrane domain polymorphisms in COPD from South-Indian population
2016, Egyptian Journal of Medical Human GeneticsCitation Excerpt :It is suggested to play a role in the airway remodelling of the lungs [24]. Genetic linkage analysis and association studies of families with asthma across diverse ethnic back-grounds support a relationship between ADAM33 polymorphisms and asthma phenotypes expressed in AHR and other respiratory disorders [25–28]. The mouse orthologue of ADAM33 also lies in the region linked to AHR [14].
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Supported by the Dutch Asthma Funds grant AF 95.09, and National Institutes of Health (NIH) grants R01HL/48341 and R01HL/66393.