The “injury response”: A concept linking nonspecific injury, acute rejection, and long-term transplant outcomes☆
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Impact of Cold Ischemia Time on Kidney Transplant: A Mate Kidney Analysis
2020, Transplantation ProceedingsCitation Excerpt :In this study, taking into account the paired origin of the grafts, we analyzed CIT and its consequences. CIT has been shown to be an independent risk factor for DGF, but the “best” CIT is still controversial [1–9,12,13–16]. In this study, we found that CIT > 20 hours is a risk factor for DGF, in agreement with other studies [1,2,5,9,15].
Strategies to Reduce Ischemia Reperfusion Injury in Vascularized Composite Allotransplantation of the Limb
2017, Journal of Hand SurgeryInterleukin-1α activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1 receptor-2: Implications for allograft rejection
2015, Journal of Biological ChemistryCitation Excerpt :Interestingly, despite activation of caspase-1, we see no evidence of IL-1β activity in necrotic EC lysates, suggesting that ECs either do not express pro-IL-1β or that it is compartmentalized away from the caspase-1 activity. These and previous data (6, 7) also suggest that the burden of injury hypothesis (3) and the immune modulation hypothesis (1) of graft rejection cannot be mutually exclusive. Necrotic ECs cannot activate IL-1α without initial damage to vessels that cause release of active IL-1α from VSMCs or other sources, However, once primed, ECs can subsequently activate IL-1α upon necrosis and in addition up-regulate adhesion molecules such as intercellular adhesion molecule 1 and E-selectin, leading to recruitment of leukocytes.
Transplanting the elderly: Balancing aging with histocompatibility
2015, Transplantation Reviews
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Supported by the Medical Research Council of Canada, Kidney Foundation of Canada, Sandoz Canada, Hoffmann-La Roche, Royal Canadian Legion, and Muttart Foundation.