Muscarinic control of airway function
References (40)
- et al.
Eur. J. Pharmacol.
(1993) - et al.
Life Sci.
(1995) - et al.
Life Sci.
(1993) - et al.
J. Allergy Clin. Immunol.
(1994) - et al.
Eur. J. Pharmacol.
(1996) - et al.
J. Allergy Clin. Immunol.
(1988) - et al.
Eur. J. Pharmacol.
(1988) - et al.
Eur. J. Pharmacol.
(1995) - et al.
Eur. J. Pharmacol.
(1989) - et al.
Eur. J Pharmacol.
(1993)
Eur. J. Pharmacol.
Naunyn-Schmiedeberg's Arch. Pharmacol.
Br. J. Pharmacol.
Br. J. Pharmacol.
Can. J. Physiol. Pharmacol.
J. Appl. Physiol.
Br. J. Pharmacol.
Am. J. Respir. Crit. Care Med.
J. Appl. Physiol.
Cited by (59)
The effect of tiotropium in combination with olodaterol on house dust mite-induced allergic airway disease
2017, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Muscarinic receptor signaling in the airways is primarily induced via the parasympathetic neurotransmitter acetylcholine released by both neuronal and non-neuronal cells including lung structural and inflammatory cells [7]. Signaling induces bronchoconstriction and mucus production by acting on smooth muscles and mucus-secreting cells in the central airways [8–11]. Blocking the receptor using therapeutic muscarinic receptor antagonists results in smooth muscle relaxation and reduced mucus production [12].
The impact of bilateral vagotomy on the physostigmine-induced airway constriction in ferrets
2017, Respiratory Physiology and NeurobiologyBronchodilator activity of the selective muscarinic antagonist revatropate in horses with heaves
2013, Veterinary JournalCitation Excerpt :Consequently, inhalation therapy with muscarinic antagonists such as ipratropium has proven efficacy in attenuating airway obstruction in cases of heaves (Hoffman et al., 1993; Robinson et al., 1993; Duvivier et al., 1997). Revatropate offers potential advantages over non-specific antimuscarinic agents such as ipratropium, since it has significantly greater selectivity for the M3 and M1 muscarinic receptors on airway smooth muscle which mediate bronchoconstriction (Zaagsma et al., 1997) than for M2 receptors on cardiac muscle, thereby reducing undesirable cardiac effects such as tachycardia (Alabaster, 1997). Furthermore, unlike ipratropium, revatropate does not block the presynaptic inhibitory M2 receptors which may potentiate bronchoconstriction (Alabaster, 1997).
Regulation of Lower Airway Function
2011, Fetal and Neonatal Physiology E-Book, Fourth EditionChanges in muscarinic cholinergic receptor expression in human peripheral blood lymphocytes in allergic rhinitis patients
2008, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Peripheral blood lymphocytes (PBLs) express the acetylcholine biosynthetic and catabolic enzymes [20] as well as M2, M3, M4 and M5 receptor subtypes [21,22]. A relationship between changes of lymphocyte cholinergic markers and central and peripheral cholinergic dysfunction has been suggested [23–31]. Moreover, increased lymphocyte muscarinic receptor expression has also been found in asthma patients with different degree of bronchial hyperreactivity documented by MIC hyperresponsiveness [32,33].
Altered ion transport and responsiveness to methacholine and hyperosmolarity in air interface-cultured guinea-pig tracheal epithelium
2007, Journal of Pharmacological and Toxicological Methods