Original articlesSynergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus
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Should antihistamines be re-considered as antiasthmatic drugs as adjuvants to anti-leukotrienes?
2013, European Journal of PharmacologySynthesis and structure-activity relationships of γ-carboline derivatives as potent and selective cysLT<inf>1</inf> antagonists
2009, Bioorganic and Medicinal Chemistry LettersEffect of combined montelukast and desloratadine on the early asthmatic response to inhaled allergen
2005, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Roquet et al23 investigated the combination of high-dose zafirlukast (80 mg twice daily) and loratadine (10 mg twice daily) administered for 8 days on the EAR and LAR and found that combination therapy was more effective at inhibiting the EAR than either drug alone; however, the difference between the inhibition after zafirlukast was not significantly different from the inhibition after combination therapy. A more recent in vitro investigation of the H1 antihistamine chlorpheniramine and the LTRA MK-571 documented a synergistic effect of the combination versus either drug alone in allergic isolated human bronchi.24 We could identify no published data describing the effect on allergen-induced airway responsiveness after montelukast in combination with an antihistamine.
Cysteinyl leukotrienes in allergic inflammation: Strategic target for therapy
2005, ChestCitation Excerpt :This effect is enhanced in small, clinically significant bronchi (inner diameter, 0.5 to 2 mm), where they are 30-fold more potent than in larger bronchi (inner diameter, 4 to 6 mm).109 LTRAs decrease this bronchoconstriction.109,110 In small bronchi isolated from macroscopically normal sections of human lung removed during carcinoma surgery, montelukast and its two main metabolites produced parallel rightward (antagonist) shifts in the concentration-response curves for LTC4-, LTD4-, and leukotriene E4-induced bronchoconstriction.109
Evaluation of the efficacy of antihistamines using human monocyte-derived dendritic cells stimulated with histamine
2003, Journal of the American Academy of DermatologyLeukotriene modifiers
2002, Medical Clinics of North America