EditorialsMaintaining gut homeostasis: The butyrate–NF-κB connection☆
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Cited by (21)
Effect of dietary sodium butyrate supplementation on growth, blood biochemistry, haematology and histomorphometry of intestine and immune organs of Japanese quail
2019, AnimalCitation Excerpt :Once SB reaches the stomach (proventriculus and gizzard) of the bird, it quickly releases the sodium and, due to the low pH, butyrate is rapidly converted to the undissociated form, also termed butyric acid. Sodium butyrate can benefit in improving food safety (Cerisuelo et al., 2014), have positive impacts on growth performance (Hu and Guo, 2007; Zhang et al., 2011) and plays an expanded role in intestinal homeostasis (Hodin, 2000). In additiony, butyrate seems to play a role in the intestinal epithelium development of bird through stimulating the duodenal mucosa growth (Hu and Guo, 2007).
Anti-inflammatory effects of cellulose nanofiber made from pear in inflammatory bowel disease model
2014, Bioactive Carbohydrates and Dietary FibreCitation Excerpt :During pathological states, NF-κB is activated by the degradation of IκB. Once activated, NF-κB translocates from the cytoplasm to the nucleus of the cell and mediates the expression of various pro-inflammatory cytokines, initiating the inflammatory cascade (Hodin, 2000; Inan et al. 2000). In vitro studies have revealed that butyrate suppresses the immune response by inhibiting NF-κB activation (Lim, Ferguson, & Tannock, 2005; Lührs et al. 2002).
An update on alternatives to antimicrobial growth promoters for broilers
2011, Veterinary JournalCitation Excerpt :Indeed, butyric acid has been shown to be an important energy source for gut epithelial cells and to stimulate epithelial cell proliferation and differentiation (Dalmasso et al., 2008). Butyric acid also has well documented anti-inflammatory effects (Hodin, 2000) and has been shown to strengthen the gut mucosal barrier by increasing production of antimicrobial peptides in mucous and by stimulating the expression of tight junction proteins (Mariadason et al., 1997; Schauber et al., 2003; Bordin et al., 2004; Peng et al., 2007). Thus for some acids, especially butyric acid, not only antibacterial but also host effects can play a role in the AGP-replacement effect.
Butyrate Suppression of Colonocyte NF-κB Activation and Cellular Proteasome Activity
2001, Journal of Biological ChemistryDietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats
2007, British Journal of Nutrition
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Address requests for reprints to: Richard Hodin, M.D., Department of Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215. Fax: (617) 667-7756; e-mail: [email protected].