Original PaperHigh resolution computed tomography in adult cystic fibrosis patients with mild lung disease
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Radiology of Bronchiectasis
2022, Clinics in Chest MedicineCitation Excerpt :Such scores often only consider limited numbers of imaging variables and are therefore easier to perform. CT variables used in multidimensional bronchiectasis scores include bronchiectasis extent used in the FACED score (forced expiratory volume in 1 second [FEV1], age, chronic colonization, extension, and dyspnea)12,39,40 or in the Bronchiectasis Severity Index: bronchiectasis extent or the presence of cystic bronchiectasis.41,42 The Bronchiectasis Radiologically Indexed CT Score considers bronchiectasis severity and the number of bronchopulmonary segments containing emphysema.
Distribution of early structural lung changes due to cystic fibrosis detected with chest computed tomography
2013, Journal of PediatricsCitation Excerpt :The right upper lobe was most commonly affected by bronchiectasis, although there was no overall upper lobe predominance, due in part to a relatively low frequency of abnormalities detected in the left upper lobe. This could explain observations in previous studies using chest CT6-9 and chest radiography14 that report an upper lobe predominance for structural changes. Although CF lung disease is traditionally considered to affect the upper lobes more than the lower lobes, we failed to demonstrate an overall upper lobe predominance for any structural lung disease component in the young children with early disease, but the lobe most commonly affected by bronchiectasis was the right upper lobe.
Allergic Bronchopulmonary Aspergillosis
2008, Pediatric Respiratory MedicineLaboratory markers for COPD in "susceptible" smokers
2006, Clinica Chimica ActaNormal and cystic fibrosis airway surface liquid homeostasis: The effects of phasic shear stress and viral infections
2005, Journal of Biological ChemistryCitation Excerpt :Third, there has always been the perplexing question in the natural history of CF lung disease whereby the upper lobes develop disease before the lower lobes (54). Because of gravitational effects, the upper lobes are ventilated less (by ∼50%) than the lower lobes (55). The reduced upper lobe tidal volume would reduce airflow-induced shear on airway epithelia, leading to less local nucleotide release.