Original ArticlesDetection of extrathoracic metastases by positron emission tomography in lung cancer
Section snippets
Patients
Between February 1994 and September 1997 we performed FDG PET in 107 patients with NSCLC diagnosed by cytology or histology. Only patients who qualified for surgical therapy were included in the study. All patients who underwent neoadjuvant therapy were excluded.
In 2 patients definitive histologic diagnosis revealed small cell lung cancer, and 5 patients were excluded because of incomplete data. Preoperative staging included history, physical examination, and blood tests as well as chest x-ray
Histologic examination of the primary tumor
Of the 100 patients with NSCLC, 53 had squamous cell carcinoma, 38 had adenocarcinoma, and 9 had large cell carcinoma. In women the distribution was as follows: 5 had squamous cell carcinoma (25% of female patients), 14 had adenocarcinoma (70%), and 1 had large cell carcinoma (5%). In men 48 squamous cell carcinomas (60% of male patients), 24 adenocarcinomas (30%), and 8 large cell carcinomas (10%) were found.
Extrathoracic metastases
Unexpected ETM were detected at 14 sites in 13 (14%) of the patients, who were stage
Comment
Our prospective study in patients with NSCLC was originally designed to evaluate the role of FDG PET for mediastinal N staging. Use of FDG PET for mediastinal N staging is limited with respect to the exact anatomic differentiation of N1/N2 in the hilar region. However, N3 stage is detected reliably.
In this previously published study a high accuracy in detecting malignant lesions in the mediastinum could be achieved. This might be related to our highly qualified team of nuclear physicians and a
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