Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients
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Association Between Homocysteine Level and Methylenetetrahydrofolate Reductase Gene Polymorphisms in Type 2 Diabetes Accompanied by Dyslipidemia
2020, Chinese Medical Sciences JournalSerum homocysteine level and eye involvement in Egyptian patients with Behçet's disease
2014, Egyptian RheumatologistCitation Excerpt :Ocular involvement occurs in 50–70% of patients [3], and is characterized by periphlebitis, periarteritis, vascular occlusion, and thrombosis, which may lead to blindness despite intensive treatment [4]. The central feature of the histopathology of BD is an obliterative and necrotizing vasculitis that affects both the arteries and veins [5]. Homocysteine, derived from methionine, is a sulfur containing essential amino acid.
Plasma homocysteine is associated with ischemic findings without organic stenosis in patients with slow coronary flow
2013, Journal of CardiologyCitation Excerpt :The main detrimental effects of Hcy are probably on vascular endothelium. The proposed mechanism by which endothelium is damaged by Hcy is impairment of the basal production of nitric-oxide (NO) in consequence of the emergence of some biochemically active products such as hydrogen peroxide (H2O2), superoxide anion (O2−) and hydroxyl radical (HO) [9,10,18–20]. In humans, reports demonstrated that elevated Hcy level was associated with impaired endothelium-dependent vasodilation and suggested that the bioavailability of NO was decreased in hyperhomocyst(e)inemic persons [18].
Ethanol-induced increased endogenous homocysteine levels and decreased ratios of SAM/SAH are only partially attenuated by exogenous glycine in developing chick brains
2008, Comparative Biochemistry and Physiology - C Toxicology and PharmacologyCardiovascular effects of Danshen
2007, International Journal of Cardiology
This study was supported in part by Jewish Hospital Medical Research Grants 738, 2728, and 733.