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Repeated and persistent infection with Chlamydia and the development of chronic inflammation and disease

https://doi.org/10.1016/0966-842X(94)90542-8Get rights and content

Abstract

Chlamydia trachomatis is an important human pathogen that mediates disease processes capable of inflicting permanent damage.

Aggressive inflammatory responses to repeated infections and to a persistent form of this intracellular bacterium, are thought to initiate the pathogenic events that lead to the debilitating sequelae of blinding trachoma and infertility.

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      To determine whether and how the GI tract CT serve as a reservoir for autoinoculating the genital tract in humans, well-controlled large-scale clinical studies are required. Although chlamydial persistence in the genital tract has been proposed, there is no direct evidence and it is difficult to differentiate persistent infection from reinfection [82]. On the contrary, CM infection in the female mouse genital tract is hardly persistent, lasting only about 4–6 weeks, depending on the specific mouse strains [8], after which chlamydial organisms or genomes were no longer detectable in either vaginal swabs or in the genital tissue, including the oviduct/ovary tissues [10,60,83].

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