Original contributionThe inhibitory effect of extracts of cigarette tar on electron transport of mitochondria and submitochondrial particles
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Abnormalities of the optic disc
2011, Handbook of Clinical NeurologyCitation Excerpt :It was first described by Traquair in 1930 and is still prevalent in some Asian and African countries. Growing evidence suggests that ROS and cyanide derived from tobacco may disrupt the mitochondrial respiratory chain, damage mtDNA, and alter mitochondrial morphology (Kennedy and Elliot, 1970; Pryor et al., 1992; Ballinger et al., 1996). It is probably the combination of cyanide toxicity from tobacco and nutritional deficiencies of thiamine, riboflavin, pyridoxine, and/or vitamin B12 that contributed to the pathophysiology of TAA.
Investigating the receptor-independent neuroprotective mechanisms of nicotine in mitochondria
2005, Journal of Biological ChemistryCitation Excerpt :That nicotine did not prevent MPP+ and calcium-induced cytochrome c release in the presence of rotenone, a complex I inhibitor, and succinate, a substrate of complex II–IV, suggests that complexes II–IV of the mitochondrial respiratory chain are not directly involved in that process. In fact, nicotine was also found to have negligible effect on either mitochondria swelling or membrane potential in the same conditions (rotenone and succinate), further supporting the lack of interaction between nicotine and complex II–IV (44). mPTP is thought to be directly modulated by both electron flux and proton electrochemical difference (26).
Optic nerve degeneration and mitochondrial dysfunction: Genetic and acquired optic neuropathies
2002, Neurochemistry InternationalIn vitro effects of nicotine on mitochondrial respiration and superoxide anion generation
2001, Brain ResearchCitation Excerpt :To date, the effects of nicotine on mitochondrial respiration have not been demonstrated. A previous study reported an inhibitory effect of cigarette tar extracts on the various mitochondrial electron transport complexes, but the authors did not observe any effect of nicotine alone on succinate-driven mitochondrial respiration (complexes II–V respiration) [25]. These results are in agreement with the present data.
Electron spin resonance characterization of the NAD(P)H oxidase in vascular smooth muscle cells
2001, Free Radical Biology and Medicine