Superoxide dependent iron release from ferritin in inflammatory diseases

doi:10.1016/0891-5849(88)90026-3

Free Radical Biology and Medicine

Volume 4, Issue 3, 1988, Pages 185-198

https://doi.org/10.1016/0891-5849(88)90026-3 Get rights and content

Abstract

Convincing evidence is presented that oxygen free radicals are involved in the pathogenesis of rheumatoid arthritis (RA). Superoxide is produced by polymorphonuclear leucocytes (PMN) in synovial fluid and by macrophages in the synovial membrane. Tissue damage typical for the free radical attack is detected in RA. No absolute deficiency of protective factors is found in RA compared to controls, but the available protection is insufficient to cope with all radicals formed. The toxicity of superoxide is increase by iron. It is doubtful whether a low molecular weight iron pool is presented. Superoxide is able to release iron from ferritin, providing a suitalbe source of iron, for the formation of hydroxyl radicals. This new pathogenetic mechanism stimulates to the application of iron chelators in the treatment of RA. Preliminary results with desferrioxamine were disappointing because of serious side-effects. Hopefully in the future intra-articular injection of iron chelators with better pharmacodynamics will possible. The interaction of free radicals and ferritin is probably also involved in the pathogenesis of other inflammatory diseases such as systemic lupus erythematosus, hepatitis, and haemochromatosus.

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Review articleSuperoxide dependent iron release from ferritin in inflammatory diseases

Abstract

Immunochemistry

Biochim. Biophys. Acta

Adv. Free Radical Biol. Med.

J. Invest. Dermatol.

Am. Heart J.

Gastroenterology

J. Mol. Cell. Cardiol.

Prostaglandins Med.

Ann. Rheum. Dis.

Biochim. Biophys. Acta

J. Biol. Chem.

FEBS Lett.

Biochem. Biophys. Res. Comm.

Lancet

Lancet

Am. J. Med.

J. Free Radical Biol. Med.

Biochem. Biophys. Res. Comm.

Biochem. Pharmacol.

Am. J. Med.

Arch. Biochem. Biophys.

FEBS Lett.

FEBS Lett.

FEBS Lett.

FEBS Lett.

Biological defense mechanism. The production by leucocytes of superoxide, a potent bactericidal agent

J. Clin. Invest.

The pathophysiology of superoxide: Roles in inflammation and ischemia

Can. J. Physiol. Pharmacol.

Role of oxygen derived free radicals and metabolites in leukocyte-dependent inflammatory reactions

Am. J. Pathol.

Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury

J. Clin. Invest.

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Phil. Trans. R. Soc. Lond. Biol.

Oxygen toxicity, oxygen radicals, transition metals and disease

Biochem. J.

The epidemiology of rheumatoid arthritis: A review

Bull. Rheum. Dis.

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Arthritis Rheum.

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N. Engl. J. Med.

Cellular, molecular and genetic characteristics of T cell reactivity to collagen in man

Fecal clostridium perfringens and rheumatoid arthritis

J. Infect. Dis.

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Ann. Rheum. Dis.

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Ann. N. Y. Acad. Sci.

Serum antibody in rheumatoid arthritis reactive with a cell-associated antigen: Demonstration by precipitation and immunofluorescence

Arthritis Rheum.

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J. Exp. Med.

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J. Exp. Med.

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J. Clin. Invest.

The major histocompatibility system in man

Synovial Fluid and its examination

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J. Clin. Invest.

Chronic granulomatous disease

Pediatr. Clin. North. Am.

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J. Clin. Pathol.

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis

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Direct activation of neutrophil chemiluminescence by rheumatoid sera and synovial fluid

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Review article
Superoxide dependent iron release from ferritin in inflammatory diseases