Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets☆
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Cited by (43)
Subtype-specific plasma signatures of platelet-related protein releasate in acute pulmonary embolism
2022, Thrombosis ResearchCitation Excerpt :In our study, machine learning-based approaches differentiated a higher expression of P-selectin in the plasma from patients with DVT-associated PE compared to iDVT, suggesting a relation with DVT disease severity. In line with the importance of leukocyte recruitment via adhesive sP-selectin interactions, the chemokines MCP-3 (CCL7) and ENA-78 (CXCL5), preferentially activating and attracting leukocytes [62–64], presented with more highly expression in the plasma of DVT-associated PE compared to iDVT, too. Accordingly, myeloperoxidase (MPO), mediating the production of hypochlorous acid, was also upregulated in this PE subtype.
Platelets are not just for clots
2015, Transfusion Medicine ReviewsCitation Excerpt :CXCL1 is able to promote both neutrophil recruitment [77] and arrest of monocytes under flow conditions [78]. CXCL5 has significant structural homology with NAP-2 [79] and shares its ability to induce neutrophil chemotaxis [80] with a similar potency to IL-8 [81]. In addition to being a chemoattractant for neutrophils, IL-8 is also able to stimulate neutrophil degranulation and enhance expression of Mac-1 [82].
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On request, the authors will supply detailed experimental evidence for the conclusions reached in this Brief Note.