Original article
Levels of IgE in serum from normal children and allergic children as measured by an enzyme immunoassay

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Abstract

Serum IgE levels of 346 nonallergic and 301 allergic children were measured by an enzyme immunoassay. The data are presented as the geometric mean ± 95% confidence interval for each age from less than 1 to 12 years of age with those 13 to 16 years of age, pooled. The geometric mean for nonallergic patients increases from 0.9 IU/ml at less than 1 year of age to 45.4 IU/ml at 13 to 16 years of age. By use of an IgE value between confidence intervals of allergic and nonallergic subjects, a cutoff value for each age was established to differentiate allergic from nonallergic children. This value increases from 10 IU/ml at less than 1 year to 100 IU/ml at 13 to 16 years of age. The diagnostic sensitivity and specificity of the assay, based on the cutoff values, average 83% and 91%, respectively.

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