Elsevier

Thrombosis Research

Volume 12, Issue 1, January 1978, Pages 79-90
Thrombosis Research

Paper
Vascular sequestration of heparin

https://doi.org/10.1016/0049-3848(78)90087-7Get rights and content

Abstract

Heparin was administered intravenously and by intratracheal instillation to rats. With 3H-heparin, radioactivity accumulated in endothelium and vessel wall of aorta and vena cava. These vessels were also removed from rats receiving higher doses of cold heparin, extracted for mucopolysaccharides and heparin identified and measured by microelectrophoresis. This procedure revealed the presence of more heparin on the endothelium of the aorta than of the vena cava. Despite the presence of high radioactivity in the vessel wall denuded of endothelium, no heparin was obtained by the chemical extraction, suggesting a heparin metabolizing activity in the endothelium and/or vessel wall. Heparin was also administered intravenously to rats and by intratracheal instillation to mice. The drug was identified by light and electron microscopy in the endothelial tissue of rat aorta and of mouse pulmonary vessels.

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