Effects of altered platelet number on pulmonary hypertension and platelet sequestration in monocrotaline pyrrole-treated rats
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2001, ChestCitation Excerpt :Most reports describe patients who had elevated platelet counts, and there are reports of patients whose symptoms mirrored the changes in platelet counts.2 Platelet-derived growth factor released from activated platelets is a strong stimulus for smooth muscle hyperplasia,17 and in an animal model of PH the control of the platelet count retards the development of PH.18 Twelve of our patients were receiving aspirin before PH was diagnosed, and this suggests that aspirin may not be effective in preventing the onset of PH in these patients. Often, patients with CMDs have evidence of chronic disseminated intravascular coagulation19 and this can result in microthrombosis in the pulmonary circulation with PH as a consequence.
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1997, Journal of Surgical ResearchCellular fibronectin and von Willebrand factor concentrations in plasma of rats treated with monocrotaline pyrrole
1996, Biochemical PharmacologyChemical-induced vasculature injury. Summary of the symposium presented at the 32nd annual-meeting of the society of toxicology, new-orleans, louisiana, march 1993
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1995, Toxicology and Applied PharmacologyPlatelets and α-naphthylisothiocyanate-induced liver injury
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