Morphometric model for pulmonary diffusing capacity I. Membrane diffusing capacity
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Cited by (119)
Can DL<inf>NO</inf>/DL<inf>CO</inf> ratio offset prejudicial effects of functional heterogeneities in acinar regions?
2020, Respiratory Physiology and NeurobiologyCitation Excerpt :Using these DLCO and DLNO values, we calculated DMCO and Vc, obtaining 62 mL/min/mmHg for DMCO and 101 mL for Vc when KDNO/CO, θNO, and θCO values are 2.34, 60, and 0.56, respectively; thus, physiologic DMCO/Vc amounts to 0.61/mmHg/min at a resting condition. Based on the enormous studies with regard to the lung morphometry by Weibel et al. (Weibel, 1963, 2017; Weibel et al., 1993, 2005; Haefeli-Bleuer and Weibel, 1988; Hsia et al., 2016), we assumed that the best values of morphometric DMO2 and Vc at TLC level, where single-breath DLCO and DLNO are measured, are 308 mL/min/mmHg and 180 mL, respectively. These morphometric values were obtained from the air-filled, perfusion-fixed human lung at inflation level of TLC.
What are appropriate values of relative krogh diffusion Constant of NO against CO and of theta-NO in alveolar septa?
2020, Respiratory Physiology and NeurobiologyMorphometric and morphological study of the respiratory organs of the bimodally-breathing African sharptooth catfish (Clarias gariepinus): Burchell (1822)
2018, ZoologyCitation Excerpt :Anatomically, it correlates directly with surface area and inversely with thickness of the barrier (Fig. 2F). Compared with the τt, the τht is the more appropriate parameter for determining Dto2 (Weibel and Knight, 1964; Weibel, 1970/71; Hughes, 1972; Maina and Maloiy, 1986; Weibel et al., 1993; da Costa et al., 2007). For the gills, Dto2 was determined from the TGRSA and the τht(WBB) as follows:Dto2 = (Kto2 x TGRSA)/τht(WBB)Kto2 is the Krogh’s O2 diffusion coefficient across the tissue barrier.
Air blood barrier phenotype correlates with alveolo-capillary O<inf>2</inf> equilibration in hypobaric hypoxia
2017, Respiratory Physiology and NeurobiologyThe blood transfer conductance for CO and NO
2017, Respiratory Physiology and NeurobiologyCitation Excerpt :There is no direct evidence for or against this proposition, but a companion paper (Borland et al., 2017) argues that an infinite value for θNO in vivo is feasible. Physiologically, an infinite θNO in vivo means a lower estimate of DMCO, (and higher 1/DMCO and so lower Rrc/RTot% for CO) and one which, even on exercise, is much lower than morphometric measurements of membrane diffusing capacity (Weibel et al., 1993). With a finite θNO, estimates of DMCO on exercise, using a combined NO–CO analysis, approach morphometric estimates.