Elsevier

Metabolism

Volume 30, Issue 6, June 1981, Pages 616-634
Metabolism

Metabolic basis for disorders of purine nucleotide degradation☆

https://doi.org/10.1016/0026-0495(81)90142-6Get rights and content

Abstract

Purine nucleotide degradation refers to a regulated series of reactions by which human purine ribonucleotides and deoxyribonucleotides are degraded to uric acid in humans. Two major types of disorders occur in this pathway. A block of degradation occurs with syndromes involving immune deficiency, myopathy or renal calculi. Increased degradation of nucleotides occurs with syndromes characterized by hyperuricemia and gout, renal calculi, anemia or acute hypoxia. Management of disorders of purine nucleotide degradation is dependent upon modifying the specific molecular pathology underlying each disease state.

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    • Cited by (0)

    ☆

    This work supported in part by USPHS grants AM 19674 and 5M01RR42, and grants from the Michigan Heart Association and the Warner Lambert Company.

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