Brief note
Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro

https://doi.org/10.1016/0012-1606(89)90322-9Get rights and content

Abstract

Amoeboid microglial cells purified from primary cultures of embryonic rat brains and stimulated with bacterial lipopolysaccharides released high amounts of nerve growth factor. This finding suggests that brain macrophages play a major neurotrophic role during development, in adulthood, and in the regenerative events that follow localized lesions.

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This work was supported by INSERM, DRET, and FRM.

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