Brief noteLipopolysaccharide-stimulated rat brain macrophages release NGF in vitro☆
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Cited by (197)
Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation
2017, NeuropharmacologyCitation Excerpt :Microglial cells are also a source of growth factors, suggesting that they provide trophic support for glia and neurons (Elkabes et al., 1996). Activated microglia have been linked with neuroprotection in several studies, and it has been suggested that glial cells are activated in response to neuronal injury, with subsequent release of neurotrophic factors, such as nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5, that exhibit neuroprotective effects (Mallat et al., 1989; Lindsay et al., 1994; Elkabes et al., 1996; Nakajima et al., 2001). Neurotrophic activity has been reported for the C-terminal end of γ-enolase (Hattori et al., 1995; Hafner et al., 2012) that is needed for its translocation towards the plasma membrane.
Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity
2015, NeuropharmacologyCitation Excerpt :In addition to the canonical cytokines (e.g. IL-1β, IL-6 and TNF-α), both resting and activated microglia can produce a range of soluble factors also capable of modulating synaptic function (reviewed in (Morris et al., 2013; Streit and Xue, 2012; Wong, 2013)). These include trophic factors (e.g. BDNF (Batchelor et al., 1999; Elkabes et al., 1996; Nakajima et al., 2002; Suzuki et al., 2001) and NGF (Frade and Barde, 1998; Mallat et al., 1989)), neurotransmitters, and neuromodulators. Microglia undergo significant changes in the aging brain.
Dynamic structural remodelling of microglia in health and disease: A review of the models, the signals and the mechanisms
2014, Brain, Behavior, and ImmunityCitation Excerpt :Similarly, as neurons themselves migrate and extend afferent and efferent projections, microglia transition to branched, ramified shapes that support the actions of developing neurons (Dalmau et al., 1997a). Ramified microglia are also known to express neurotrophic molecules that would assist in guiding neuronal projections, such as plasminogen and neural growth factor (Mallat et al., 1989; Nakajima et al., 1992). The majority of research on microglial morphology has occurred in situations of extensive neuroinflammation.
Metchnikoff's policemen: Macrophages in development, homeostasis and regeneration
2011, Trends in Molecular MedicineCitation Excerpt :This function is important, as Csf1op/op mice display abnormal endocrine physiology [35,37], an effect largely rescued by injection of Csf1 and activation of brain microglia. Interestingly, microglia are also important sources of nerve growth factor (NGF), a potent neuron growth and survival factor [37,38], as well as other related neuron-inducing factors [39]. The role of myeloid NGF is complex as myeloid NGF induced neuron apoptosis in the developing chick retina by activating the neurotrophin receptor p75 [14].
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This work was supported by INSERM, DRET, and FRM.