Elsevier

Biochemical Pharmacology

Volume 45, Issue 9, 5 May 1993, Pages 1769-1774
Biochemical Pharmacology

Elevation of cysteine and replenishment of glutathione in rat lung slices by cysteine isopropylester and other cysteine precursors

https://doi.org/10.1016/0006-2952(93)90432-VGet rights and content

Abstract

In this study, we have used a rat lung slice model to compare the ability of several potential cysteine delivery systems (l-cysteine isopropylester, l-cysteine cyclohexylester, N-acetylcysteine, l,2-oxo-4-thiazolidine carboxylic acid and cysteine) to elevate cysteine and glutathione (GSH) levels in control lung slices and slices depleted of their GSH by diethyl maleate. The esters of cysteine produced the greatest rise in lung slice cysteine. All the cysteine delivery systems were capable of replenishing GSH in lung slices previously depleted of GSH by diethyl maleate.

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