Lung preservation: The importance of endothelial and alveolar type II cell integrity
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Impact of the cardiac arrest mode on cardiac death donor lungs
2015, Journal of Surgical ResearchPhysiologic assessment of the ex vivo donor lung for transplantation
2012, Journal of Heart and Lung TransplantationAlveolar preservation with high inflation pressure and intermediate oxygen concentration reduces ischemia-reperfusion injury of the lung
2012, Journal of Heart and Lung TransplantationCitation Excerpt :Together, this will result in a lower concentration of surfactant in the alveolus at the start of reperfusion, which causes increased surface tension at the alveolocapillary barrier, leading to alveolar collapse, accumulation of anaerobic metabolites, hypoxic vasoconstriction, and hypoperfusion. Furthermore, higher shear forces are developed due to surfactant injury, leading to stress injury of the alveolar epithelium and capillary endothelium subsequent increased capillary permeability, and protein-rich edema formation.8,17 Because surfactant is rate-limiting for the transfer of proteins across the alveolocapillary membrane, a further influx of proteins is facilitated, which dose-dependently further inhibits surfactant and results in a cascade of surfactant inactivation.18
Protective Mechanism of Ultrafiltration Against Cardiopulmonary Bypass-Induced Lung Injury
2009, Transplantation Proceedings
Supported by grants from the Heart and Stroke Foundation of Ontario and the Multi-Organ Transplant Service, London Health Sciences Centre, University Campus.