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Mucosa-associated lymphoid tissue lymphoma studied with FDG-PET: a comparison with CT and endoscopic findings

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Abstract

Objective

We investigated the accumulation of 2-deoxy-2-[18F] fluoro-d-glucose positron emission tomography (FDG-PET) in patients with mucosa-associated lymphoid tissue (MALT) lymphoma patients as compared with computerized tomography (CT) and endoscopic imaging.

Methods

FDG-PET was performed on 13 untreated patients with MALT lymphoma. CT scanning of the affected areas was performed in all the patients to compare with the FDG-PET images. In five patients with gastric MALT lymphoma, comparison was also made with the endoscopic findings.

Results

Of the 13 untreated MALT lymphoma patients, all 8 non-gastric MALT lymphoma patients exhibited abnormal accumulation of FDG. However, in the five gastric MALT lymphoma patients, no abnormal FDG accumulation was observed. Although lesions could be confirmed on CT images from the patients other than those with gastric MALT lymphoma, the mucosal lesions of gastric MALT lymphoma could be observed only by endoscopy.

Conclusions

FDG-PET can be used to detect MALT lymphoma when it forms mass lesions, whereas it is difficult to detect non-massive MALT lymphoma of gastrointestinal origin.

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Authors and Affiliations

  1. Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Keisuke Enomoto, Kenichiro Hamada & Jun Hatazawa

  2. Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Keisuke Enomoto, Hidenori Inohara & Takeshi Kubo

  3. Department of Clinical Oncology and Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Ichiro Higuchi

  4. Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

    Yasuhiko Tomita

Authors
  1. Keisuke Enomoto
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  2. Kenichiro Hamada
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  3. Hidenori Inohara
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  4. Ichiro Higuchi
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  5. Yasuhiko Tomita
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  6. Takeshi Kubo
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  7. Jun Hatazawa
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Correspondence to Keisuke Enomoto.

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Enomoto, K., Hamada, K., Inohara, H. et al. Mucosa-associated lymphoid tissue lymphoma studied with FDG-PET: a comparison with CT and endoscopic findings. Ann Nucl Med 22, 261–267 (2008). https://doi.org/10.1007/s12149-007-0125-9

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  • DOI: https://doi.org/10.1007/s12149-007-0125-9

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