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Validation of a Quality of Life Questionnaire for Bronchiectasis: psychometric analyses of the Spanish QOL-B-V3.0

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Abstract

Purpose

Bronchiectasis is a chronic disease, leading to worsening of health-related quality of life. This study evaluated the psychometric properties of a new patient-reported outcome for non-cystic fibrosis bronchiectasis, the Quality of Life Questionnaire Bronchiectasis, translated into Spanish (QOL-B-Sp-V3.0).

Methods

This prospective study recruited clinically stable patients with non-cystic fibrosis bronchiectasis at 4 Spanish centers. Health status was assessed with multiple indicators (dyspnea, exacerbations, bronchorrhea, etc.), microbiological, radiological, spirometric, and anthropometric parameters plus St-George Respiratory Questionnaire (SGRQ). Psychometric analyses included internal consistency, test–retest reliability, convergent validity, predictive validity, and responsivity to change.

Results

The 207 stable patients (mean age 57.2 years) had a Bhalla score of 11.53 ± 7.39 and FEV1% of 68.3 ± 22.2 %. One hundred and sixty-one stable patients repeated the test 2 weeks later, and 80 patients who had an exacerbation within 6 months of the assessment also repeated it. Internal consistency was high across all scales (Cronbach’s alpha >0.70). Thirty-six of 37 items correlated more strongly with their assigned scale than a competing scale. Test–retest coefficients were strong (intraclass correlations r = 0.68–0.88). All scales, except Treatment Burden, discriminated significantly between patients with mild, moderate, and severe disease according to FEV1% and other respiratory parameters. Strong convergence was found between the QOL-B-Sp-V3.0 and SGRQ. Significant correlations were found between QOL-B-Sp-V3.0 and various clinical, spirometric, radiological, and anthropometric variables. Significant differences were found on all QOL-B-Sp-V3.0 scales, except emotional functioning, between the baseline responses and onset of an exacerbation; robust sensitivity to change was observed on the Respiratory Symptoms scale.

Conclusions

The QOL-B-Sp-V3.0 questionnaire demonstrated strong reliability and validity. Scores were reproducible after 2 weeks, and it discriminated between patients who varied in severity and was responsive to changes related to exacerbation.

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Abbreviations

BQ:

Bronchiectasis

BMI:

Body mass index

CDRQ:

Chronic Respiratory Disease Questionnaire

CF:

Cystic fibrosis

CFQ-R:

Cystic Fibrosis Questionnaire Revised

FEV1 :

Forced spirometry volume in the first second

HI:

Haemophilus influenzae

HRCT:

High-resolution computed tomography

HRQOL:

Health-related quality of life

LCQ:

Leicester Cough Questionnaire

MID:

Minimal important difference score

MRC:

Medical Research Council

PA:

Pseudomonas aeruginosa

PRO:

Patient-reported outcome

QOL-B-Sp:

Quality of Life Questionnaire for patients with Bronchiectasis. Spanish version

SEPAR:

Spanish Society of Pulmonology and Thoracic Surgery

SGRQ:

St. George Respiratory Questionnaire

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Acknowledgments

This study was supported by a grant from SEPAR (31/2011).

Author information

Authors and Affiliations

  1. Pneumology Service, Hospital Regional Universitario de Málaga. IBIMA (Instituto de Investigación Biomédica de Málaga), Universidad de Málaga, Avenida Carlos Haya, 29010, Malaga, Spain

    Casilda Olveira & Francisco Espildora

  2. Endocrinology and Nutrition Service, Hospital Regional Universitario de Málaga. IBIMA (Instituto de Investigación Biomédica de Málaga), Universidad de Málaga, Malaga, Spain

    Gabriel Olveira

  3. CIBERDEM, CIBER of Diabetes and Associated Metabolic Diseases (Instituto de Salud Carlos III), Madrid, Spain

    Gabriel Olveira

  4. Pneumology Service, La Princesa Hospital, Madrid, Spain

    Rosa-Maria Giron

  5. Pneumology Service, Idibgi, Hospital Universitari Dr Josep Trueta, Gerona, Spain

    Gerard Muñoz

  6. Department of Psychology, University of Miami, Coral Gables, FL, USA

    Alexandra L. Quittner

  7. Pneumology Service, Polytechnic and University La Fe Hospital, Valencia, Spain

    Miguel-Angel Martinez-Garcia

Authors
  1. Casilda Olveira
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  2. Gabriel Olveira
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  3. Francisco Espildora
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  4. Rosa-Maria Giron
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  5. Gerard Muñoz
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  6. Alexandra L. Quittner
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  7. Miguel-Angel Martinez-Garcia
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Corresponding author

Correspondence to Casilda Olveira.

Additional information

This study is included in the PII of Bronchiectasis of SEPAR (Spanish Society of Pulmonology and Thoracic Surgery).

Montserrat Vendrell (Universitary Hospital Dr Josep Trueta, Gerona, Spain) and Nuria Porras (Endocrinology and Nutrition Service, Carlos Haya University Hospital, Malaga, Spain) also participated in this study.

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Olveira, C., Olveira, G., Espildora, F. et al. Validation of a Quality of Life Questionnaire for Bronchiectasis: psychometric analyses of the Spanish QOL-B-V3.0. Qual Life Res 23, 1279–1292 (2014). https://doi.org/10.1007/s11136-013-0560-0

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