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Inflammatory Manifestations in Chronic Granulomatous Disease (CGD)

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Abstract

Chronic granulomatous disease (CGD) is a genetically heterogeneous disease characterized by recurrent life-threatening infections with bacteria and fungi as well as dysregulated inflammatory mechanisms. CGD is caused by defects in the NADPH oxidase, the enzyme complex responsible for generation of superoxide and other reactive oxygen species (ROS) in phagocytic cells. In this review we will focus our attention on those particular inflammatory manifestations associated with CGD, their frequencies and the underlying immunologic mechanisms favoring it occurrence.

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Notes

  1. Carneiro-Sampaio M, Chairperson, XII LAGID Meeting/I BRAGID Meeting, Autoimmunity in primary immunodeficiencies. São Paulo, August, 16–18th, 2007.

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Acknowledgment

The author has no conflict of interests to declare. SDR’s work is supported by the National Institutes of Health, Fogarty International Center and the Fogarty International Research Collaboration Award, Grant R01TW006644.

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  1. Servicio de Inmunología, Hospital Nacional de Pediatría J. P. Garrahan, Combate de los Pozos 1881, (1245), Buenos Aires, Argentina

    S. D. Rosenzweig

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Correspondence to S. D. Rosenzweig.

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Rosenzweig, S.D. Inflammatory Manifestations in Chronic Granulomatous Disease (CGD). J Clin Immunol 28 (Suppl 1), 67–72 (2008). https://doi.org/10.1007/s10875-007-9160-5

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