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Comparison of right ventricular functions by tissue Doppler imaging in patients with obstructive sleep apnea syndrome with or without hypertension

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Abstract

Objective

To evaluate the right ventricular function in patients with obstructive sleep apnea syndrome (OSAS) independent from systemic hypertension (HT) and to determine the association between OSAS severity and right ventricular dysfunction.

Methods

The study population included 77 consecutive subjects; 20 of these patients had OSAS, 20 of them had HT, but did not have OSAS, 16 patients, who constituted the study group, had both disorders, and 21 subjects without any of these two disorders represented the control group. Right ventricular function was assessed by echocardiography: standard two-dimensional, M-Mode, and conventional Doppler as well as tissue Doppler imaging. None of the patients had a previous history of cardiac disease. The diagnosis of OSAS was based on an apnea- hipopnea index of 5 or higher in polysomnography.

Results

Tricuspid inflow velocities and tissue Doppler derived tricuspid annular diastolic velocities were significantly different in the patient groups (OSAS, HT, OSAS + HT) compared to the control group. Tricuspid annular plane systolic excursion (TAPSE) (18.3 ± 3.2, 18.4 ± 2.5, 20.1 ± 2.1, and 20.7 ± 2.5 mm, respectively, P = 0.024) and peak systolic myocardial velocity at tricuspid lateral annulus (S-vel) (12.2 ± 1.5, 10.9 ± 0.9, 11.2 ± 1.1, and 13.1 ± 2.1 cm/s, respectively, P < 0.001) were significantly lower in patient groups compared to those of the study group. Tissue Doppler derived myocardial performance index (MPI) of the right ventricle was significantly impaired in the patient groups compared to the control group (0.34 ± 0.06, 0.44 ± 0.06, 0.45 ± 0.07, and 0.41 ± 0.06, respectively, P < 0.001). With regard to these right ventricular functional parameters, there was no significant difference between OSAS and the other patient groups (HT and OSAS + HT). There were significant correlations both between OSAS severity and the right ventricular functions, and between diastolic and systolic parameters of the right ventricle (r = −0.45, P < 0.05).

Conclusion

Both right ventricular systolic and diastolic functions are impaired in patients having OSAS with or without HT. Right ventricular MPI was found to be the parameter most closely related with OSAS severity and the right ventricular subclinical dysfunction.

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Authors and Affiliations

  1. Department of Cardiology, Gazi University Medical School, Erzurum m. Gul s. 5/23, Cebeci, Ankara, Turkey

    Yusuf Tavil, Nihat Şen, Adnan Abacı, M. Rıdvan Yalçın & Atiye Çengel

  2. Department of Pulmonary Disease, Gazi University Medical School, Ankara, Turkey

    Asiye Kanbay, Tansu Ulukavak Çiftçi & Oğuz Köktürk

Authors
  1. Yusuf Tavil
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  2. Asiye Kanbay
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  3. Nihat Şen
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  4. Tansu Ulukavak Çiftçi
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  5. Adnan Abacı
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  7. Oğuz Köktürk
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  8. Atiye Çengel
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Correspondence to Yusuf Tavil.

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Tavil, Y., Kanbay, A., Şen, N. et al. Comparison of right ventricular functions by tissue Doppler imaging in patients with obstructive sleep apnea syndrome with or without hypertension. Int J Cardiovasc Imaging 23, 469–477 (2007). https://doi.org/10.1007/s10554-006-9168-6

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  • DOI: https://doi.org/10.1007/s10554-006-9168-6

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