Abstract
Objective: In normal infants, functional residual capacity using plethysmography (FRCpleth) exceeds FRCN2 (using nitrogen washout) and the within-subject difference FRC(pleth−N2) indicates the part of pulmonary gas volume not ventilated during tidal breathing. We postulated that infants with bronchopulmonary dysplasia (BPD) have an elevated FRC(pleth−N2). Design: In a prospective study, FRC(pleth−N2) in healthy newborns (controls n = 17) was compared to that in neonates recovering from the respiratory distress syndrome without BPD (noBPD, studied at discharge, n = 13) and with BPD (BPD1 n = 14, studied at 36 post-conceptional weeks; BPD2 n = 16, at discharge). Measurements and results: Paired measurements, FRCpleth and FRCN2, were performed using a plethysmograph (Jaeger, Germany) and an open-circuit nitrogen washout technique (SensorMedics 2600, USA). In comparison to the controls (5.2 ml/kg), FRC(pleth−N2)/kg in noBPD (12.7 ml/kg, p < 0.001), in BPD1 (24.9 ml/kg, p < 0.001) and in BPD2 (13.5 ml/kg, p < 0.001) was significantly higher. Compared with that of the controls FRCpleth was significantly increased in BPD1 (p < 0.001) and FRCN2 was decreased in noBPD and both BPD groups. Conclusion: The FRC(pleth−N2) is a reliable indicator for pulmonary inhomogeneities in infants with respiratory diseases.
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Received: 15 July 1997 Accepted: 26 January 1998
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Wauer, R., Maurer, T., Nowotny, T. et al. Assessment of functional residual capacity using nitrogen washout and plethysmographic techniques in infants with and without bronchopulmonary dysplasia. Intensive Care Med 24, 469–475 (1998). https://doi.org/10.1007/s001340050598
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DOI: https://doi.org/10.1007/s001340050598