Abstract.
Cystic Fibrosis (CF) is the most common lethal genetic disease in the Caucasian population and typically results in the development of bronchial inflammation, bronchiectasis, the progressive loss of lung function and ultimately death. Recently it has been shown that products of the Th17 subset of T-cells, specifically, IL-17A and IL-17F are elevated in the sputum of CF patients. This review will go over experimental evidence supporting a role for the IL- 23/IL-17 axis in CF lung inflammation.
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Received 13 November 2006; returned for revision 11 December 2006; accepted by M. Parnham 14 December 2006
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Dubin, P.J., McAllister, F. & Kolls, J.K. Is cystic fibrosis a TH17 disease?. Inflamm. res. 56, 221–227 (2007). https://doi.org/10.1007/s00011-007-6187-2
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DOI: https://doi.org/10.1007/s00011-007-6187-2