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Variable response to inhaled salbutamol of different lung function parameters in healthy children

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Abstract

We compared changes in different lung function parameters (airway conductance and forced expiration parameters) after inhalation of salbutamol in 49 healthy school children. Bronchomotor tone (expressed by sGaw) was found to be reducible in 92% of the children.

Changes in sGaw after inhalation (mean 63.4%) were found to be highly significant (P < 0.001) and most sensitive in evaluating bronchodilatation, while changes in FEV1 (mean 6.3%), PEFR (mean 5.8%) and FEF75 (mean 5.9%) were of less or no significance. Large airway compression on forced expiration due to reduced airway wall rigidity after bronchodilation is a possible explanation of these results.

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Riedel, F., von der Hart, H. Variable response to inhaled salbutamol of different lung function parameters in healthy children. Lung 164, 333–338 (1986). https://doi.org/10.1007/BF02713658

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  • DOI: https://doi.org/10.1007/BF02713658

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